Recently,immunosenscence is becoming one of the hot topic in the research field of basic immunology and immunotherapy. Although there are many theories and mechanisms of human aging, the function of immune cells (such as T cells and NK cells etc.) is directly related to their excessive differentiation and aging. In vitro activation and "awakening" of the immune cell vigor of the organism, can increase the anti-disease and anti-aging function of the immune effector cells to improve own health.